BMSEED
BioMedical Sustainable Elastic Electronic Devices
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In Vivo Brain Research

In Vivo Brain Research

Electrodes for brain research and clinical applications

Surface of the skull – Electroencephalography (EEG)

  • Pros:
    • Non-invasive, stable recordings over time        
  • Cons:
    • Low spatial and temporal resolution

Surface of the brain - Electrocorticography (ECoG)

  • Pros:
    • Less invasive than penetrating electrodes
    • High signal-to-noise 
    • Stable recordings over time
  • Cons:
    • More invasive than EEG

Inside the brain - Penetrating electrodes 

  • Pros:
    • High signal-to-noise ratio (close to the neurons)
  • Cons:
    • Highly invasive (Inserted into the brain)
    • Signal/noise and neuronal environment deteriorate over time
    • Accessible cortex area is limited

BMSEED is developing a microelectrode array for electrocorticography (ECoG) for research and clinical applications that (i) has a higher spatial resolution than commercial ECoGs, (ii) accesses a larger area of the cortex, and (iii) has improved grid compliance and therefore improved safety compared to current micro ECoGs (ECoG).

A major clinical application of ECoG electrodes is the pre-surgical localization of epileptogenic zones in the brains of patients with epilepsy. Epilepsy is the 4th most common neurological problem in the United States with an estimated 150,000 new cases each year and a prevalence estimated at about 2.3 million adults and 470,000 children age 0-17. About 30% of patients with epilepsy have seizures that cannot be controlled by medication, and therefore require surgery, and 80–84% of epilepsy surgery centers around the world perform ECoG in some or all of their patients with partial epilepsy.  


ECoG electrode array

 

Pedestal to securely mount the ECoG on the skull without hurting the animal.