In Vitro Research Without sacrificing relevance

In vitro research has many advantages over in vivo research, such as (1) tight control of chemical and physical environment, (2) it is cheaper, and (3) faster, and (4) fewer animals are needed. However, isolated and cultivated primary cells to differ from the corresponding cell type in an organism, limiting the value of in vitro data to predict in vivo behavior. A major reason for this divergence is that in vitro experiments do not replicate the mechanical and electrical environment of cells in an organism. MEASSuRE addresses this weakness by reproducing the mechanical and electrical environment of cells in vivo in a controlled environment in vitro.


Physiological Stretching of Cells

Tissue Engineering
Stem cells that differentiate into a specific tissue have properties that resemble adult tissue more closely when the cells are under mechanical and electrical stimulation during the differentiation process. MEASSuRE has the capability to provide both, electrical and mechanical stimulation. 

Drug Toxicity Testing
Tissues grown from stem cells differentiated under mechanical and electrical stimulation are more representative of their respective organ in an adult human. Thus, the validity of drug toxicity testing by pharmaceutical company increases. MEASSuRE has the capability to provide both, electrical and mechanical stimulation.

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Mechano-Biology
There are a variety of mechanisms for transducing and sensing mechanical forces in neurons and other cell types. MEASSuRE provides capabilities to fundamentally understand the effect of mechanical forces.