In Vitro Research Without sacrificing relevance
Every year more than 1.7 million Americans sustain a traumatic brain injury (TBI) or concussion, and 12,000-20,000 sustain a spinal cord injury (SCI). Despite the billions of dollars spent on research and drug development over the past decades, little is known about the mechanisms of neurotraumatic injuries, and ALL 35 clinical trials for neuroprotective drugs have failed. In most cases, the primary biomechanical mechanism of the cell damage is a pathological stretch of the brain tissue during the impact. MEASSuRE reproduces the biomechanics of a TBI, SCI, or concussion in a controlled environment in vitro. Multiple injuries can be produced for investigating the effects of repeated concussions and the link to neurodegerative diseases. MEASSuRE allows functional drug screening to directly assess the efficacy of drug candidates, accelerating the pre-clinical drug discovery process.
Pathological Stretching of Cells
Neurotrauma Research and Treatments
MEASSuRE allows to reproduce reliably and repeatedly the biomechanics of traumatic brain injury and spinal cord injury in a controlled environment. Changes in the electrophysiology of the injured neurons can be assessed in a straightforward manner with the embedded microelectrodes by comparing the post-injury electrophysiology to pre-injury level. The effectiveness of drugs or other treatment strategies to minimize the damage after injury cantherefore be readily assessed.
MEASSuRE will allow researchers and physicians to develop improved concussion protocols that are based on the electrophysiology of the underlying injury rather than cognitive tests.
Muscle Injury Research and Treatments
MEASSuRE will allow the investigation of the mechanism of those muscle injuries that are caused by excessive tension or compression, and the evaluation of drugs to speed up recovery.
Mechanisms on Stem Cell Repair Research
Stem cells are involved in repair processes after injury in different parts of the body, e.g., in the brain after a traumatic brain injury. The mechanism of the activation of the mechanoreceptors is not understood. MEASSuRE will be a useful tool to elucidate and study this mechanism.
Other – Research on Neurodegenerative Diseases
Neurodegenerative diseases such as Alzheimer’s disease have common pathological pathways with traumatic brain injury, e.g., the build-up of amyloid-plaques. Therefore, MEASSuRE might be a valuable tool for the early evaluation of the efficacy of drug candidates against Alzheimer’s disease.