In Vitro Research
To Better Predict
In Vivo Behavior

Reproduce Cellular Biomechanics in vitro Using Stretchable Microelectrodes For Electrophysiology & Imaging Data That More Accurately Represent in vivo Behavior

 
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MEASSuRE: 3 methods, 1 tool

Reproduces the electrical and mechanical environment of cells in the body. Using BMSEED’s proprietary stretchable microelectrode arrays (sMEAs), this tool combines electrophysiology, mechanical stretching, and imaging to produce more accurate, relevant data.

 
 

Stretchable MicroElectrode Array

Our stretchable MEAs are incorporated with the MEASSuRE system. They provide the only method for researchers to manipulate chemical, electrical, and mechanical factors independently to more closely replicate the complexity of the human body.

 

Accurate Data

Simulate the cell’s natural environment in the body to generate more relevant in vitro data.

Efficient Workflow

Concurrently apply multiple paradigms with MEASSuRE to save time, money, and research animals.

Unrivaled Results

Better predict clinical outcomes by eliminating drug candidates early & reduce failure rate in clinical trials.

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What Our Customers Say

Tuneable parameters and very fast to use.”

-Alyssa Pybus, Ph.D. Georgia Tech

Easiness for acquiring electrical signal in a non-invasive manner.”

-Alex Patino, Ph.D. Arizona State University

“The most valuable thing is that we can record from cells multiple times…injure and record on the same device.”

-Mary Kate Dwyer, M.S. Columbia University

a) organotypic hippocampal slice cultures (OHSCs), long-term potentiation (LTD) & long-term depression (LTD) induced post-injury; b) primary hippocampal neurons (PHNs) & brain tissue tolerance to traumatic brain injury (TBI); c) organotypic spinal cord slice cultures (OSCSCs) & cypin regulated pain sensitivity after spinal cord injury (SCI); d) human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), hiPSC-CM differentiation; e) neurons, astrocytes, & microglia, pro-inflammatory signaling & immune response to mild traumatic brain injury (mTBI)


Publications

 
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The effects of bending on the resistance of elastically stretchable metal conductors, and a comparison with stretching

O. Graudejus, T. Li, J. Cheng, N. Keiper, R.D. Ponce Wong, A.B. Pak, J. Abbas

Applied Physics Letters, 2017, 110, 221906

 
 

Alterations in Hippocampal Network Activity after In Vitro Traumatic Brain Injury

W. H. Kang, W. Cao, O. Graudejus, T. Patel, S. Wagner, D. Meaney, B. Morrison III

Journal of Neurotrauma, 2015, 32(13), 1011-1019

 
 

Monitoring Hippocampus Electrical Activity In Vitro on an Elastically Deformable Microelectrode Array

Z. Yu, O. Graudejus, C. Tsay, S. P. Lacour, S. Wagner, B. Morrison

Journal of Neurotrauma, 2009, 26(7):1135-1145

 
 

Integrating Cellular Biomechanics with Electrophysiology

Instrumentation for Life Science Research to Better Predict In Vivo Behavior

Contact us today!

 
 
 
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